Publications by Type: Journal Article
In this article, we develop and make available measures of public ideology in 2010 for the 50 American states, 435 congressional districts, and state legislative districts. We do this using the geospatial statistical technique of Bayesian universal kriging, which uses the locations of survey respondents, as well as population covariate values, to predict ideology for simulated citizens in districts across the country. In doing this, we improve on past research that uses the kriging technique for forecasting public opinion by incorporating Alaska and Hawaii, making the important distinction between ZIP codes and ZIP Code Tabulation Areas, and introducing more precise data from the 2010 Census. We show that our estimates of ideology at the state,
congressional district, and state legislative district levels appropriately predict the ideology of legislators elected from these districts, serving as an external validity check.
Objective: To evaluate the effectiveness of a physician-led rapid response team (RRT) program on morbidity and mortality following unplanned admission to the pediatric intensive care unit (PICU). Design: Before-after study. Setting: Single center quaternary referral PICU. Patients: All unplanned PICU admissions from the ward from 2005-2011. Interventions: The dataset was divided into pre- and post-RRT groups for comparison. Measurements and Main Results: A Cox proportional hazards model was used to identify the patient characteristics associated with mortality following unplanned PICU admission. Following RRT implementation, PRISM-III illness severity was reduced 28.1%, PICU length of stay (LOS) was less 19.8%, and mortality declined 22%. Relative risk of death following unplanned admission to the PICU after RRT implementation was 0.685. Conclusions: For children requiring unplanned admission to the PICU, RRT implementation is associated with reduced mortality, admission severity of illness and length of stay. RRT implementation led to more proximal capture and aggressive intervention in the trajectory of a decompensating pediatric ward patient.
Inpatient care for children with severe traumatic brain injury (sTBI) is expensive, with inpatient charges averaging over $70,000 per case (Hospital Inpatient, Children Only, National Statistics. Diagnoses– clinical classification software (CCS) principal diagnosis category 85 coma, stupor, and brain damage, and 233 intracranial injury. Diagnoses by Aggregate charges [https://hcupnet.ahrq.gov/#setup]). This ranks sTBI in the top quartile of pediatric conditions with the greatest inpatient costs (Hospital Inpatient, Children Only, National Statistics. Diagnoses– clinical classification software (CCS) principal diagnosis category 85 coma, stupor, and brain damage, and 233 intracranial injury. Diagnoses by Aggregate charges [https://hcupnet.ahrq.gov/#setup]). The Brain Trauma Foundation developed sTBI intensive care guidelines in 2003, with revisions in 2012 (Kochanek, Carney, et. al. PCCM 3:S1-S2, 2012). These guidelines have been widely disseminated, and are associated with improved health outcomes (Pineda, Leonard. et. al. LN 12:45-52, 2013), yet research on the cost of associated hospital care is limited. The objective of this study was to assess the costs of providing hospital care to sTBI patients through a guideline-based Pediatric Neurocritical Care Program (PNCP) implemented at St. Louis Children’s Hospital, a pediatric academic medical center in the Midwest United States.
Objective: Our goal was to identify risk factors for acute kidney injury (AKI) in children surviving cardiac arrest (CA). Design: Retrospective analysis of a public-access dataset. Setting: Fifteen children’s hospitals associated with the Pediatric Emergency Care Applied Research Network. Patients: Two hundred ninety-six subjects between 1 day and 18 years of age who experienced in-hospital or out-of-hospital CA between July 1, 2003, and December 31, 2004. Interventions: None. Measurements and Main Results: Our primary outcome was development of AKI as defined by the Acute Kidney Injury Network (AKIN) staged criteria. An ordinal logistic model was developed using 8 candidate variables. We found 6 critical explanatory variables, including total number of epinephrine doses, post-CA blood pressure, arrest location, presence of a chronic lung condition, pH nadir, and presence of an abnormal baseline creatinine. Conclusions: This study is the first to identify risk factors for AKI in children after CA. Our findings regarding the impact of epinephrine dosing are of particular interest and suggest potential for epinephrine toxicity with regard to AKI. The ability to identify and potentially modify risk factors for AKI after CA may lead to improved morbidity and mortality in this challenging population. Key Words: cardiac arrest; children; pediatric; outcome; acute kidney injury; epinephrine.
To understand how the nature of scientific collaboration between individuals and sites in team-based research initiatives affect collaboration and research output, we examined four waves of prospective survey data to measure collaboration across investigators, disciplines, and sites to measure structural determinants of research success. 116 investigators in the five sites of the NIH-funded U54 Transdisciplinary Research on Energetics and Cancer (TREC) initiative were surveyed about their research ties with a 2011 baseline measure and followed by three additional iterations and augmented by bibliometric data. Social network analysis describes the changing structure of contact and cooperation. We found that the network structure of a team science project affects the nature and rate of publications, implying that funded projects vary in research output based on how investigators interact with each other and that the design of scientific research projects affects research output by determining levels of contact between actual and potential collaborators. Keywords: cancer; research; transdisciplinarity; team science; network models.
BACKGROUND AND OBJECTIVES: Phlebotomy excess contributes to anemia in PICU patients and increases the likelihood of red blood cell transfusion, which is associated with risk of adverse outcomes. Excessive phlebotomy reduction (EPR) strategies may reduce the need for transfusion, but have not been evaluated in a PICU population. We hypothesized that EPR strategies, facilitated by implementation science methods, would decrease excess blood drawn and reduce transfusion frequency. METHODS: Quantitative and qualitative methods were used. Patient and blood draw data were collected with survey and focus group data to evaluate knowledge and attitudes before and after EPR intervention. The Consolidated Framework for Implementation Research was used to interpret qualitative data. Multivariate regression was employed to adjust for potential confounders for blood overdraw volume and transfusion incidence.